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\"A masterful distillation of permaculture in a way that is easy to apply to our gardens, farms, and lives today.\" -David Cody, founder, Urban Permaculture Institute Once a fringe topic, permaculture is moving to the mainstream as gardeners who are ready to take their organic gardening to the next level are discovering the wisdom of a simple system that emphasizes the idea that by taking care of the earth, the earth takes care of you. The Vegetable Gardener's Guide to Permaculture teaches gardeners of every skill-with any size space-how to live in harmony with both nature and neighbours to produce and share an abundant food supply with minimal effort. Permaculture teacher Christopher Shein highlights everything you need to know to start living off the land lightly, including how to create rich, healthy, and low-cost soil, blend a functional food garden and decorative landscape, share the bounty with others, and much more.

A just-in-time guide for revamping distressed companies Drawn from the author's decades of experience advising, purchasing, and reviving distressed companies across industries, geographies, and sizes, Reversing the Slide is designed to help executives, managers, and employees revitalize downtrodden companies. It shows how to: select the tactics appropriate for each stage of distress; understand the use of entrepreneurial concepts; avoid pitfalls common to turnarounds; determine the legal, financial, strategic, and operational steps in the process; discover why the principal of \"ready, fire, aim\" should guide the decision-making process in situations with time pressure and significant uncertainty; and uncover the secrets of effective leadership and governance.\n\n \n\nContains step-by-step instructions for helping troubled organizations bounce back with vigor\nOften quoted in the Wall Street Journal, the author is an authority on restructuring and downsizing\nOffers a handbook for implementing a successful corporate turnaround\n\n James Shein's Reversing the Slide is full of insightful advice on what works, what does not, and why it will prove invaluable to executives, managers, and employees in helping troubled companies before it's too late.

Praise for the Second Edition:\n\n\"… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study.\" -Biometrics\n\n\"This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered …\" – Journal of the Royal Statistical Society\n\nSample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation.\n\nFeatures:\n\n\n\n \n\n \nCompares the relative merits and disadvantages of statistical methods for sample size calculations\n \n\n \nExplains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages\n \n\n \nPresents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women’s health\n \n\n \nProvides sample size calculations for dose response studies, microarray studies, and Bayesian approaches\n\nThis new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.

Reviews critical issues (e.g., endpoint/margin selection, sample size requirement and complex innovative design).\nProvides better understanding of statistical concepts and methods which may be used in regulatory review and approval.\nClarifies controversial statistical issues in regulatory review and approval.\nMakes recommendations to accurately and reliably evaluate rare diseases regulatory submissions.\nProposes innovative study designs and statistical methods for rare diseases drug development including n-of-1 trial design, adaptive trial design, and master protocols such as platform trials.\nProvides insight regarding current regulatory guidance on rare diseases drug development such as gene therapy.

Praise for the Second Edition:\n\n\"… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study.\" -Biometrics\n\n\n\n\"This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered …\" – Journal of the Royal Statistical Society\n\n\n\nSample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation.\n\n\n\nFeatures:\n\n\n\n\n\n\n\n\n\n \nCompares the relative merits and disadvantages of statistical methods for sample size calculations\n\n\n \n\n\n\n \nExplains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages\n\n\n \n\n\n\n \nPresents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women’s health\n\n\n \n\n\n\n \nProvides sample size calculations for dose response studies, microarray studies, and Bayesian approaches\n\n\n \n\n\n\nThis new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.

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